Nano Chemotherapeutics in Bone Metastasis and Targeting
نویسندگان
چکیده
منابع مشابه
Targeting FSTL1 prevents tumor bone metastasis and consequent immune dysfunction.
Bone metastasis greatly deteriorates the quality of life in patients with cancer. Although mechanisms have been widely investigated, the relationship between cancer bone metastasis and antitumor immunity in the host has been much less studied. Here, we report a novel mechanism of bone metastasis mediated by FSTL1, a follistatin-like glycoprotein secreted by Snail(+) tumor cells, which metastasi...
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Recent advances in the understanding of prostate cancer biology and its progression to bone metastasis have led to the development of drugs directed against precise molecular alterations in the prostate tumor cell and host cells in the normal bone environment such as osteoclasts and osteoblasts. Endothelins (ETs) and their receptors have emerged as a potential target in prostate cancer bone met...
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Background: Bone metastasis is common in different cancers, and increases morbidity and mortality. The goals of this study were to develop nanoparticles (NPs) to treat bone metastasis, and advance mesenchymal stem cell (MSC)-based repair of lost bone by enhancing osteogenesis and enabling image guided cell implantation and longitudinal monitoring. Methods: Nanoparticles were formulated from pol...
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Prostate cancer (PCa) bone metastases have long been believed to be osteoblastic because of bone remodeling leading to the formation of new bone. However, recent studies have shown increased osteolytic activity in the beginning stages of PCa bone metastases, suggesting that targeting both osteolytic and osteoblastic mediators would likely inhibit bone remodeling and PCa bone metastasis. In this...
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Prostate cancer is the most commonly diagnosed cancer in men within the western world and the third leading cause of cancer-related deaths. Even if the cancer is considered localized to the prostate, there is a 15% to 20% incidence of subsequent metastatic disease. Prostate cancer has a very high proclivity for metastasizing to bone, with approximately 90% of men with advanced disease having sk...
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ژورنال
عنوان ژورنال: Turkish Journal of Pharmaceutical Sciences
سال: 2016
ISSN: 1304-530X,2148-6247
DOI: 10.4274/tjps.2016.12